Murine Equivalent of the Human Histo-blood Group ABO Gene Is acis-AB Gene and Encodes a Glycosyltransferase with Both A and B Transferase Activity

Miyako Yamamoto, Xiao-Hong Lin, Yoshihiko Kominato, Yukiko Hata, Reiko Noda, Naruya Saitou, Fumiichiro Yamamoto
2001 Journal of Biological Chemistry  
We have cloned murine genomic and complementary DNA that is equivalent to the human ABO gene. The murine gene consists of at least six coding exons and spans at least 11 kilobase pairs. Exon-intron boundaries are similar to those of the human gene. Unlike human A and B genes that encode two distinct glycosyltransferases with different donor nucleotide-sugar specificities, the murine gene is a cis-AB gene that encodes an enzyme with both A and B transferase activities, and this cis-AB gene
more » ... ls in the mouse population. Cloning of the murine AB gene may be helpful in establishing a mouse model system to assess the functionality of the ABO genes in the future.
doi:10.1074/jbc.m010805200 pmid:11278752 fatcat:zob4yad7gbd2pkgwq6gqivgqya