Intramolecular base composition heterogeneity of human DNA

Douglas L. Vizard, Frank P. Rinehart, Carol M. Rubin, Carl W. Schmid
1977 Nucleic Acids Research  
The intramolecular base composition heterogeneity of human DNA has been investigated by electron microscopic obseirvations of partially denatured structures and by equilibrium solution thermal denaturation techniques. DNA sequences having an average length of less than 2000 base pairs are found to be heterogeneous in base composition. These heterogeneous sequences occupy a minimum of 67 to 81% of the human genome.
doi:10.1093/nar/4.11.3753 pmid:593884 pmcid:PMC343198 fatcat:25vvnfs7vnaazlai2i2fx4tynq