Dynamic resolution of functionally related gene sets in response to acute heat stress

Joseph D Szustakowski, Penelope A Kosinski, Christine A Marrese, Jee-Hyung Lee, Stephen J Elliman, Nanguneri Nirmala, Daniel M Kemp
<span title="">2007</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mxhqd7nwg5gmvhv3icwfw2ylaa" style="color: black;">BMC Molecular Biology</a> </i> &nbsp;
Using a gene clustering strategy we determined intracellular pathway relationships within skeletal myotubes in response to an acute heat stress stimuli. Following heat shock, the transcriptome was analyzed by microarray in a temporal fashion to characterize the dynamic relationship of signaling pathways. Results: Bioinformatics analyses exposed coordination of functionally-related gene sets, depicting mechanism-based responses to heat shock. Protein turnover-related pathways were significantly
more &raquo; ... ffected including protein folding, pre-mRNA processing, mRNA splicing, proteolysis and proteasome-related pathways. Many responses were transient, tending to normalize within 24 hours. Conclusion: In summary, we show that the transcriptional response to acute cell stress is largely transient and proteosome-centric.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1471-2199-8-46">doi:10.1186/1471-2199-8-46</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17550601">pmid:17550601</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1904231/">pmcid:PMC1904231</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ivqm26swszgwtb27za72sxhu5i">fatcat:ivqm26swszgwtb27za72sxhu5i</a> </span>
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