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The explosion in the number of complete genomes over the past decade has spawned a new and exciting discipline, that of comparative genomics. To exploit the full potential of this approach requires the development of novel algorithms, databases and software which are sophisticated enough to draw meaningful comparisons between complete genome sequences and are widely accessible to the scientific community at large. This article reviews progress towards the development of computational tools anddoi:10.1099/mic.0.28006-0 pmid:16000703 fatcat:p5bgkzdv2zfaleuywsrftkgrry