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This paper deals with the analysis of a metabolic network with feedback inhibition. The considered system is an acyclic network of mono-molecular enzymatic reactions in which metabolites can act as feedback regulators on "preceding" enzymes of their own pathway, and in which one metabolite is the root of the whole network. We show, under mild assumptions, the uniqueness of the equilibrium. In the simplified case where inhibition only acts on the reactions having the root of the network asdoi:10.3934/nhm.2006.1.219 fatcat:onokcdi5rvgd3lb7hbsnoqhgqa