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The mechanism of the chicken cleft primary palate mutation : subtitle altered Fgf8 signalling from frontonasal mass epithelium redirects proximodistal outgrowth of the upper beak
Facial development occurs through the outgrowth and fusion of neural crest-derived facial prominences that surround the primitive oral cavity. Failure of the prominences to grow together properly can result in a number of facial deformities, of which cleft lip with or without cleft palate is the most common. A mutation known as cleft primary palate (cpp) has been discovered in the chicken that causes complete failure of outgrowth of the upper facial prominences with the consequence that adoi:10.14288/1.0090674 fatcat:vesv7rvmejgcpda2omf2kpwzc4