Assessing White Matter Microstructure in Brain Regions with Different Myelin Architecture Using MRI

Samuel Groeschel, Gisela E. Hagberg, Thomas Schultz, Dávid Z. Balla, Uwe Klose, Till-Karsten Hauser, Thomas Nägele, Oliver Bieri, Thomas Prasloski, Alex L. MacKay, Ingeborg Krägeloh-Mann, Klaus Scheffler (+1 others)
2016 PLoS ONE  
Objective We investigate how known differences in myelin architecture between regions along the cortico-spinal tract and frontal white matter (WM) in 19 healthy adolescents are reflected in several quantitative MRI parameters that have been proposed to non-invasively probe WM microstructure. In a clinically feasible scan time, both conventional imaging sequences as well as microstructural MRI parameters were assessed in order to quantitatively characterise WM regions that are known to differ in
more » ... the thickness of their myelin sheaths, and in the presence of crossing or parallel fibre organisation. . We also acknowledge support by Deutsche assessing new microstructural WM parameters we were able to provide normative data and discuss their interpretation in regions with different myelin architecture, as well as their possible application as biomarker for WM disorders. Assessing White Matter Microstructure in Brain Regions with Different Myelin Architecture PLOS ONE | 11. Stikov N, Campbell JSW, Stroh T, Lavelée M, Frey S, Novek J, et al. In vivo histology of the myelin gratio with magnetic resonance imaging.
doi:10.1371/journal.pone.0167274 pmid:27898701 pmcid:PMC5127571 fatcat:fjdfaevmxzdh5jgtf26kskaeoe