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A simple, accurate, selective & reproducible validated stability indicating assay method was developed for determination of Paclitaxel in presence of its degradation products. The best separation was achieved in the C18 analytical column at ambient temperature using a mobile phase composed of acetonitrile and phosphate buffer (60:40) in isocratic mode. The flow rate was set at 1.0 ml/min and detection wavelength was 226 nm. The drug gives peak at R T 4.95 min and forced degradation studies gavedoi:10.4172/2157-7064.1000135 fatcat:yuckppdjvrcatgoep652wtp6ki