Thieme Chemistry Journal Awardees - Where Are They Now? Asymmetric Brønsted Acid Catalyzed Transfer Hydrogenations

Magnus Rueping, Erli Sugiono, Fenja Schoepke
2010 Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry  
A s y m m e t r i c B r ø n s t e d A c i d C a t a l y z e d T r a n s f e r H y d r o g e n a t i o n s Abstract: Asymmetric hydrogenations are of great importance in the synthesis of optically active amines. This account highlights the development of the first metal-free transfer hydrogenation that is both highly enantioselective and inspired by nature's dehydrogenase. Further focus is given to the extension of this bioinspired process to provide a variety of valuable, biologically active
more » ... logically active products and natural products under mild reaction conditions.
doi:10.1055/s-0029-1219528 fatcat:kgl4zoidjneqvkp3ejptta7adi