We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F 2a , a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-a, TNF-a receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study,

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... ee human subjects were supplemented with a mixture (4·2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P¼ 0·003) compared with the control group. However, no changes in TNF-a, TNF-a receptors 1 and 2, and vascular cell adhesion molecule-1 were detected. Conjugated linoleic acid: C-reactive protein: Tumour necrosis factor-a: Inflammation * Corresponding author: Dr Annika Smedman, fax þ 46 18 611 79 76, email annika.smedman@pubcare.uu.se Abbreviations: CLA, conjugated linoleic acid; CRP, C-reactive protein; PG, prostaglandin; TNFR, tumour necrosis factor-a receptor; VCAM-1, vascular cell adhesion molecule-1.