Conjugated linoleic acid increased C-reactive protein in human subjects

Annika Smedman, Samar Basu, Stefan Jovinge, Gunilla Nordin Fredrikson, Bengt Vessby
2005 British Journal of Nutrition  
We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F 2a , a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-a, TNF-a receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study,
more » ... ee human subjects were supplemented with a mixture (4·2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P¼ 0·003) compared with the control group. However, no changes in TNF-a, TNF-a receptors 1 and 2, and vascular cell adhesion molecule-1 were detected. Conjugated linoleic acid: C-reactive protein: Tumour necrosis factor-a: Inflammation * Corresponding author: Dr Annika Smedman, fax þ 46 18 611 79 76, email annika.smedman@pubcare.uu.se Abbreviations: CLA, conjugated linoleic acid; CRP, C-reactive protein; PG, prostaglandin; TNFR, tumour necrosis factor-a receptor; VCAM-1, vascular cell adhesion molecule-1.
doi:10.1079/bjn20041419 pmid:16277783 fatcat:ox6chi63sbdwfpa7dobmjtjw2u