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Potassium isopropoxide, involved in the cycle reaction of the intermediate dehydroester, is an important coupling agent in the production of drug pipemidic acid tablets. Current production problems of potassium isopropoxide by alkali method are the long period, the low productivity and the high energy consumption. To solve these problems, the reactive distillation production process of potassium isopropoxide was studied by simulation calculation and pilot experiment. The results show that thedoi:10.37358/rc.20.9.8325 fatcat:3ijjwgngmfbjnkt5o4ykdg74ym