A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf
.
Evaluating the impact of single nucleotide variants on transcription factor binding
2016
Nucleic Acids Research
Diseases and phenotypes caused by disrupted transcription factor (TF) binding are being identified, but progress is hampered by our limited capacity to predict such functional alterations. Improving predictions may be dependent on expanding the set of bona fide TF binding alterations. Allele-specific binding (ASB) events, where TFs preferentially bind to one of the two alleles at heterozygous sites, reveal the impact of sequence variations in altered TF binding. Here, we present the largest ASB
doi:10.1093/nar/gkw691
pmid:27492288
pmcid:PMC5137422
fatcat:k7r43d5iczc3jepu5pedp56h54