Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity

W J Syu, W R Lee, B Du, Q C Yu, M Essex, T H Lee
1991 Journal of Virology  
All animal retroviruses whose nucleotide sequences have been determined contain two or three closely spaced cysteine residues in the extracellular domain of the env-encoded transmembrane protein. Using human immunodeficiency virus type 1 gp4l as a working model, the functional significance of these highly conserved cysteines was investigated. We report here that substituting the two conserved cysteine residues in this domain of gp4l with glycine residues resulted in the loss of viral
more » ... of viral infectivity, which could be attributed to severe impairment in the processing of gpl6O precursor to gpl20.
doi:10.1128/jvi.65.11.6349-6352.1991 fatcat:76j6u5sapzds7ct4bdyftxx2ym