Pasteurella pneumotropica is a Gram-negative bacterium that infects the laboratory rodents. In immunodeficient animals, P. pneumotropica infection develops mild to severe or lethal diseases. However, little is known about the transmissibility and pathogenesis of P. pneumotropica in immunodeficient mice. In this study, to assess transmissibility and its pathological conditions by P. pneumotropica, experimental contact infection model of NOD/ShiJic-scid mice was examined with clinical and

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... ical approaches. Findings: The bacteria could infect NOD/ShiJic-scid mice by experimental contact, and half of the infected mice exhibited a decrease in body weight with subsequent death. These mice displayed lung abscess lesions. P. pneumotropica was isolated from the lower respiratory tract of these mice. Conclusions: This experimental contact model achieved to facilitate P. pneumotropica transmissibility and form similar pathological process same as directly infected mice.