The unignorable N protein of COVID-19 [post]

Zehua Zeng, Zhi Luo, Yubang Shan, Jingjie Yang, Chuan Chen, Luna Wang, Hongwu Du
2020 unpublished
With more and more people infected with COVID-19, it was found that the SARS-CoV-2 virus was quite different from SARS-CoV. Most researches have focused on ACE2 and S protein, however, the known variations of these proteins are not enough to explain why there were so many different clinical manifestations between patients infected with such two viruses. Here, the N protein of the two coronaviruses was parallelly analyzed. Through the analysis of N protein structure, protein conserved binding
more » ... ain, binding site and ligand, and CTL epitope, it was found that N protein may have a unique expression profile in the SARS-CoV-2. For example, mirror structure and RNA binding tendency.
doi:10.21203/ fatcat:c5yehbrbt5fl7ocqw5yrmmacni