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The unignorable N protein of COVID-19 [post]

Zehua Zeng, Zhi Luo, Yubang Shan, Jingjie Yang, Chuan Chen, Luna Wang, Hongwu Du
2020 unpublished

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With more and more people infected with COVID-19, it was found that the SARS-CoV-2 virus was quite different from SARS-CoV. Most researches have focused on ACE2 and S protein, however, the known variations of these proteins are not enough to explain why there were so many different clinical manifestations between patients infected with such two viruses. Here, the N protein of the two coronaviruses was parallelly analyzed. Through the analysis of N protein structure, protein conserved binding
more » ... ain, binding site and ligand, and CTL epitope, it was found that N protein may have a unique expression profile in the SARS-CoV-2. For example, mirror structure and RNA binding tendency.
doi:10.21203/rs.3.rs-34518/v1 fatcat:c5yehbrbt5fl7ocqw5yrmmacni
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Zehua Zeng, Zhi Luo, Yubang Shan, Jingjie Yang, Chuan Chen, Luna Wang, Hongwu Du. "The unignorable N protein of COVID-19." (2020)