Post-print: Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients. DOI: 10.1007/s13365-015-0421-4

Hayley Goullee, Antonia Wadley, Catherine Cherry, Richard Allcock, Micheal Black, Peter Kamerman, Patricia Price
2017 Figshare  
Post-print copy of: Goullee H, Wadley AL, Cherry CL, Allcock RJN, Black M, Kamerman PR, Price P. Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients. Journal of Neurovirology 22: 508-517, 2016. DOI: 10.1007/s13365-015-0421-4. PMID: 26785644 Abstract: HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral
more » ... t (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2. HIV-SN status was assessed using the Brief Peripheral Neuropathy Screening tool, with SN defined by bilateral symptoms and signs. Forty-five SNPs in P2X7R, P2X4R and CAMKK2 were genotyped using TaqMan fluorescent probes, in DNA samples from 153 HIV(+) black Southern African patients exposed to stavudine. Haplotypes were derived using the fastPHASE algorithm, and SNP genotypes and haplotypes associated with HIV-SN were identified. Optimal logistic regression models included demographics (age and height), with SNPs (model p
doi:10.6084/m9.figshare.5374681.v1 fatcat:ssgkxse7w5dqlatxv7awevzttu