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Potential negative effects of anti-histamines on male reproductive function
Histamine (HA) is a pleiotropic biogenic amine synthesized exclusively by histidine decarboxylase (HDC) in most mammalian tissues. The literature on the role of HA within the male gonad has expanded over the last years, attracting attention to potential unexpected side-effects of anti-histamines on testicular function. In this regard, HA receptors (HRH1, HRH2 and HRH4) have been described in Leydig cells of different species, including human. Via these receptors, HA has been reported to triggerdoi:10.1530/rep-17-0685 pmid:29523718 fatcat:x35gxf4b5na53dr6swsnvb56tm