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Recent experimental evidence suggests that most of the genome is transcribed into non-coding RNAs. The initially made transcripts undergo further processing generating shorter, metabolically stable RNAs with diverse functions. Small nucleolar RNAs (snoRNAs) are non-coding RNAs acting in modification of rRNAs, tRNAs and snRNAs that were considered stable. We review evidence that snoRNAs undergo further processing. High-throughput sequencing and RNase protection experiments showed widespreaddoi:10.1002/bies.201200117 pmid:23180440 pmcid:PMC3732821 fatcat:nf4yvgymknfypkxl5nohzw7z3u