Serum testosterone as predictor of pathological stage in prostate cancer
Indian Journal of Clinical Anatomy and Physiology
Aim: The aim of our study is -To assess whether parameter as serum testosterone can be used to predict the pathological stage of the disease. To determine whether serum testosterone can be used as prognostic marker for the carcinoma prostate. To evaluate the efficacy of serum testosterone as a rapid tool in the diagnosis and prognosis of prostate carcinoma. Materials and Methods: A total of 30 patients of carcinoma prostate as a case and 30 patients of BPH as a control. Clinical staging done by
... CT/MRI. Pathological staging done after radical prostectomy. Serum, testosterone analyzed by radioimmunoassay. Statistical analysis was done using statistical software SPSS version 10.0. Data was found to be normally distributed. Statistical analysis was performed using student's 't' test with statistical significance at <0.05. Results: All patients included in this study were in age group of 50-80 years. Mean age of patients was 66.60 + 8.06 years. Mean PSA for all patients was 26.49 + 12.34 ng/ml. Minimum PSA was 8 ng/ml and maximum 89 ng/ml. 40% patients have serum testosterone > 400 ng/dl and 30% patients have serum testosterone < 200 ng/dl. Remaining 30% have serum testosterone in between 200-399 ng/dl. Mean preoperative serum testosterone level in study group were 315.30±49.66 ng/ml and in control group the mean preoperative serum testosterone level were 369.83±51.12 ng/dl. The mean serum testosterone concentration is lower in carcinoma prostate patients as compared to the BPH patients. The mean difference in both the group were statistically significant (p=0.018). In organ confined disease, the mean preoperative serum testosterone level were 411.14±11.50 ng/ml and in non-organ confined disease the mean preoperative serum testosterone level were 329.33±71.57 ng/dl. The mean serum testosterone level is lower in non-organ confined as compared to the organ confined disease. The mean difference in both organ and non-organ confined disease were statistically significant (p=0.008). Conclusion: We conclude that patients with carcinoma prostate have statistically significant correlation between pretreatment total testosterone level and pathological stage. In our study total testosterone emerged as an independent predictor of extra prostatic disease We also analyzed patients with carcinoma prostate have low serum testosterone level as compared to BHP patients.