The cannabinoid system: from the point of view of a chemist [chapter]

Raphael Mechoulam, Lumir Hanuš, David Castle, Robin Murray
Marijuana and Madness  
This book is about cannabis (marijuana) and psychotic illnesses; more specifically, it outlines how our increasing understanding of cannabis itself, the effects of cannabis on the brain and psychic functions and of the cannabinoid system can inform our understanding of the relationships between cannabis and psychosis. This chapter serves as an introduction to this topic, with a brief historical overview of the psychic effects of cannabis, followed by an exposition on the cannabinoid system.
more » ... abinoid system. Cannabis and mental illness J. J. Moreau, the first nineteenth-century psychiatrist with an interest in psychopharmacology, described in great detail his experiments with hashish (Moreau, 1973). He took the drug himself and asked his students to follow his example. He also administered it to his patients. By modern standards the doses used were enormously high. The effects on one of his assistants, who swallowed 16 g of an extract -presumably containing several hundred milligrams of tetrahydrocannabinol (THC), which we know today to be the major psychotropic principal of cannabis -were intense agitation, incoherence, delirium and hallucinations. On the basis of numerous such experiments, Moreau declared that 'there is not a single, elementary manifestation of mental illness that cannot be found in the mental changes caused by hashish, from simple manic excitement to frenzied delirium, from the feeblest impulse, the simplest fixation, the merest injury to the senses, to the most irresistible drive, the wildest delirium, the most varied disorders of feelings' . He considered hashish intoxication to be a model of endogenous psychoses, which could offer an insight into the nature of psychiatric diseases. Some of the effects described by Moreauobsessive ideas, irresistible impulses, persecutory delusions and many others -are Marijuana and Madness: Psychiatry
doi:10.1017/cbo9780511543630.003 fatcat:s57te7noijbgdggk242w7qcfy4