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Investigations were carried out to determine whether both DNA strands involved in Escherichia coli chromosomal DNA replication are replicated with similar accuracy. Experiments consisted of measuring the forward mutation rate from tonB + to tonBin pairs of polA deficient strains in which the chromosomal target gene tonB was oriented in the two possible directions relative to the origin of replication, oriC . Within these pairs, the tonB sequence would be subjected to leading strand replicationdoi:10.1266/ggs.80.1 pmid:15824450 fatcat:zjuvbs6iz5axpcucnuneudnnyu