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A New Nucleoporin-like Protein Interacts with Both HIV-1 Rev Nuclear Export Signal and CRM-1
Journal of Biological Chemistry
The HIV-1 Rev is a shuttling protein required for the nuclear export of unspliced and partially spliced viral mRNA. In this study, we have identified a new Revinteracting protein, that specifically interacts with the Rev nuclear export signal both in yeast and mammalian cells. This protein has features found in nucleoporins including many phenylalanine-glycine repeats, a very high serine content, a putative zinc finger, and a coiledcoil domain; we thus called it NLP-1 (nucleoporin-like proteindoi:10.1074/jbc.274.24.17309 pmid:10358091 fatcat:h33nn7dvpzeprmyzyd4zljdwcm