Renin-Angiotensin System Role in the Pathophysiological Progression of Coronary Dysfunction in Prediabetic Female Rats

Patrick Meagher, Yi Ching Chen, Hirotsugu Tsuchimochi, Lucinda M. Hilliard, Katrina M. Colafella, Keiji Umetani, Mikiyasu Shirai, Robert E. Widdop, Kate Denton, James T. Pearson
SPring-8/SACLA Research Report  
We investigated in female rats the coronary response to infusion of angiotensin-II type 2 receptor agonist compound 21 (C21) utilizing high resolution SR microangiography. We found that in non-diabetic rats acute C21 infusion evoked dilation in the coronary microvessels that most likely involved endothelium derived hyperpolarization factors, while C21 evoked mild constriction in prediabetic rats.
doi:10.18957/rr.8.3.473 fatcat:cksdq2c2ubc4ni3bu3jrn4a6yy