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Renin-Angiotensin System Role in the Pathophysiological Progression of Coronary Dysfunction in Prediabetic Female Rats
SPring-8/SACLA Research Report
We investigated in female rats the coronary response to infusion of angiotensin-II type 2 receptor agonist compound 21 (C21) utilizing high resolution SR microangiography. We found that in non-diabetic rats acute C21 infusion evoked dilation in the coronary microvessels that most likely involved endothelium derived hyperpolarization factors, while C21 evoked mild constriction in prediabetic rats.
doi:10.18957/rr.8.3.473
fatcat:cksdq2c2ubc4ni3bu3jrn4a6yy