Contrast-Enhanced Ultrasound Guided Pleural Biopsy Improves Diagnostic Confidence in Multidisciplinary Diagnosis of Pleural Lesions: A 3-year Prospective Study [post]

Wenwen Sun, Yiming Zhou, Cong Yang, Zhengwei Dong, ZheMin Zhang, Yin Wang, Lin Fan
2021 unpublished
Objective: To evaluate the accuracy and safety of contrast-enhanced ultrasound (CEUS) guided biopsy in the diagnosis of pleural lesions.Method: A prospective study was conducted on patients with undiagnosed pleural lesions. Patients who met the inclusion criteria received pleural biopsy guided by CEUS to obtain specimens, followed by histomathological and etiological examinations. After treatment and follow-up, surgical thoracoscopy was performed for cases of undefinite diagnosis.Result: A
more » ... osis.Result: A total of 460 patients were finally included. CEUS showed internal necrosis in 72.17% cases and peripheral obvious vessels 55.43% cases , both of which were significantly higher than the conventional ultrasound imaged (P 0.00). The diagnostic accuracy through CEUS guided biopsy sampling was 98.91% (455/460). The etiological diagnostic yield achieved 88.82% (278/313) in infectious lesions. In 330 cases combined pleural effusion, CEUS guided biopsy increased the diagnostic yield from 60.30 % (199 /330 ) to 98.36 % (325 /330) in all cases (P 0.00), from 15.56 % (14/90) to 94.44% (85/90) in malignant lesions ( P 0.00)and from 77.08 %(185/240)to 100%(240/240, P 0.00) in infectious lesions. No serious adverse events occurred. Conclusion: CEUS guided biopsy provides a minimally invasive、 effective and safe diagnostic biopsy method for pleural lesions.Clinical Trials Registration: Chinese Clinical Trial Registry ChiCTR2000029749 ( ChiCTR, www.chictr.org.cn )
doi:10.21203/rs.3.rs-424800/v1 fatcat:kkijavgyxvh5jnvrd3pt2ne7gq