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Dyslipidemia, but Not Hyperglycemia, Induces Inflammatory Adhesion Molecules in Human Retinal Vascular Endothelial Cells
2003
Investigative Ophthalmology and Visual Science
PURPOSE. The initial determinants of retinal microvascular damage in diabetic retinopathy are not well understood, but are likely to be induced by hyperglycemia and/or dyslipidemia. The purpose of this study was to examine the effect of fatty acids and hyperglycemia on human retinal vascular endothelial (hRVE) cells as a means of mimicking diabetic metabolic disorders. METHODS. The expression of adhesion molecules in hRVE and human umbilical vein endothelial cells (HUVECs) was assayed by
doi:10.1167/iovs.03-0418
pmid:14578429
fatcat:o3x7jzxqo5gibesczkgrz7resu