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A general model of invariant chain association with class II major histocompatibility complex proteins
1995
Proceedings of the National Academy of Sciences of the United States of America
The binding of invariant chain to major histocompatibility complex (MHC) proteins is an important step in processing of MHC class II proteins and in antigen presentation. The question of how invariant chain can bind to all MHC class II proteins is central to understanding these processes. We have employed molecular modeling to predict the structure of class 11-associated invariant chain peptide (CLIP)-MHC protein complexes and to ask whether the predicted mode of association could be general
doi:10.1073/pnas.92.18.8269
pmid:7667280
pmcid:PMC41138
fatcat:ahyc6nt7bzcolgm2v6mqb2jl44