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Early growth response‐1 regulates acetylcholinesterase and its relation with the course of Alzheimer's disease
Our previous studies showed that the transcription factor early growth response-1 (EGR1) may play a role in keeping the brain cholinergic function intact in the preclinical stages of Alzheimer's disease (AD). In order to elucidate the mechanisms involved, we first performed data mining on our previous microarray study on postmortem human prefrontal cortex (PFC) for the changes in the expression of EGR1 and acetylcholinesterase (AChE) and the relationship between them during the course of AD.doi:10.1111/bpa.12688 pmid:30511454 fatcat:sga3qz4nlncbnayl65r34he7bi