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Granulocyte colony-stimulating factor exacerbates cardiac fibrosis after myocardial infarction in a rat model of permanent occlusion
2008
Cardiovascular Research
Aims Controversy exists regarding the effects of granulocyte colony-stimulating factor (G-CSF) on postinfarction remodelling, which is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). The aim of this study was to investigate the impact of G-CSF administration on cardiac MMP/TIMP ratios and long-term remodelling in a rat model of acute myocardial infarction (MI). Methods and results Sprague-Dawley rats underwent coronary ligation to produce MI.
doi:10.1093/cvr/cvn202
pmid:18676396
fatcat:qtpjlsqgkfb7llzrz24ge7ybtu