Prevalence of Oral Thrush Yeasts among School Children with special emphasis of Fluconazole antifungal drug

Dr R.Venkatajothi
2017 International Journal of Current Research in Medical Sciences  
The fungus Candida albicans commonly causes of Oral thrush and when the fungus begins to grow uncontrollably, an infection can develop in the mouth. Oral thrush most often occurs in infants and children. It causes white bumps to form on the inner cheeks and tongue. This condition is also known as Oropharyngeal Candidiasis. The aim of the study was to analysis the prevalence of Oral thrush yeasts among School children and to carry out their antifungal susceptibility pattern to Fluconazole
more » ... Fluconazole antifungal agent. A total number of 325 healthy school children (200 Boys and 125 girls) from Luqman Islamic Seminary Secondary School in rural area of Dar-Es-Salaam in Tanzania were sampled for the occurrence of Oral thrush yeasts. The children were aged between 5 to 12 years old. Candida yeasts were identified by using Sabouraud Dextrose Agar media and Antifungal susceptibility testing was performed for the isolates of Candida using disc diffusion method on Mueller Hinton agar media. Among of 325 School children sampled, 42.0% isolates were found to be Candida yeasts positive and 58.0 % isolates were non Candida species. Further examination of the positive cases showed that Candida albicans occurred as 46% and Non Candida albicans species was 54%. Antifungal susceptibility was done for 62 Candida albicans isolates. Among of them 81% isolates of Candida albicans showed sensitive to Fluconazole, followed by 16% isolates showed resistance and 3% isolates were dose dependent susceptibility. The results showed that the infection occurred more in younger children below 8 year old than in older children. Further, the comparison result showed that male children have more susceptible to Candida albicans infections than the female children. The problem posed by Oral thrush to the children was highlighted and control measure recommended to reduce incidence and spread.
doi:10.22192/ijcrms.2017.03.03.016 fatcat:b2jpvgekhbgfjctymznmlt7xdm