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Natriuretic Response to Renal Medullary Endothelin B Receptor Activation Is Impaired in Dahl-Salt Sensitive Rats on a High-Fat Diet
Renal medullary endothelin B receptors (ETB) mediate sodium excretion and blood pressure (BP) control. Several animal models of hypertension have impaired renal medullary ETB function. We found that 4-week high-caloric diet elevated systolic BP in Dahl salt-sensitive (Dahl S) rats (126±2 vs. 143±3 mm Hg, p<0.05). We hypothesized that renal medullary ETB function is dysfunctional in DS rats fed a high-caloric diet. We compared the diuretic and natriuretic response to intramedullary infusion ofdoi:10.33549/physiolres.933858 fatcat:h4pl35natze5xeeaz5pjmvoxly