BACKGROUND In Rh-D haemolytic disease of foetus and newborn (HDFN), newborns can be severely affected, thereby associated with extensive morbidity and mortality. Aim-The aim of this study is to describe the clinical profile of Rh-D HDFN. Settings and Design-This was a descriptive study conducted in newborn, who had Rh-D HDFN. Setting was MATERIALS AND METHODS Enrolment of newborn was done according to inclusion criteria. Maternal and neonatal details were noted and risk of jaundice, severity of

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... disease and intensity of treatment was assessed. Statistical Analysis-All statistical data were analysed using SPSS software version 16. RESULTS 29 (65.9%) belonged to male gender and 15 (34.1%) to female gender. The mean bilirubin levels in neonates on Day 1, 2, 3, 4 and 5 were 4.15, 6.66, 9.44, 11.1 and 11.14 mg% respectively; 20 (45.5%) belonged to low risk, 13 (29.5%) to low intermediate risk, 7 (15.9%) to high intermediate risk and 4 (9.1%) to high risk categories; 4 (9.1%) belonged to no anaemia category, 17 (38.6%) belonged to mild anaemia category, 19 (43.2%) to moderate category and 4 (9.1%) to severe category; 35 (79.5%) of infants showed signs of haemolysis; 33 (75%), 7 (15.9%), 3 (6.8%) and 1 (2.3%) infants had mild, moderate, severe and very severe disease respectively; 20 (45.5%) infants required no treatment; 13 (29.5%) infants were treated only with phototherapy. IVIG was given along with phototherapy in 7 (15.9%) infants; 4 (9.1%) infants were treated with exchange transfusion along with IVIG and phototherapy. Neonates were transfused with 9 (20.5%) packed red blood cells, 3 (6.8%) platelets and 2 (4.5%) fresh frozen plasma. Results of intensity of treatment was 20 (45.5%) belonged to grade 0, 13 (29.5%) to grade 1 category; 7 (15.9%) fell into grade 2, 3 (6.8%) into grade 3 and 1 (2.3%) into grade 4 category of treatment. CONCLUSION Male infants had higher risk of developing Rh-D HDFN. Majority of infants had mild hyperbilirubinaemia and anaemia only. Disease was mild among 3/4 th of infants and almost half of the infants required no treatment.