Rearrangement of RAG-1 recombinase gene in radiation-sensitive ``wasted`` mice [report]

G.E. Woloschak, C.R. Libertin, P. Weaver, M. Churchill, Chin-Mei Chang-Liu
1994 unpublished
by a contractor of the U. S. Government under contracl No. W-31-104ENG-38. Accordongly, the U. S. Government retains a nonexcluswe. royalty-free license to publssh or reproduce the publtrhed form of thts contrburion, or allow others IO do so, for OF THIS DOCtJMENT IS UNLIMITED DISCLAIMER Portions of this document may be illegible in efectronic image products. Images are produced from the best available original document. 9 105 2 ABSTRACT f Mice recessive for the autosomal gene "wasted" (wst)
more » ... e "wasted" (wst) display a disease pattern which includes increased sensitivity to the killing effects of ionizing radiation, immunodeficiency, and neurologic dysfunction. The recent cloning and characterization of recombinase genes (RAG-l/RAG-2) expressed in lymphoid and possibly central nervous system tissues prompted us to examine expression of these genes in DNA repair-deficiendimmunodeficient wasted mice. Our results revealed expression of RAG-1 mRNA in spinal cord (but not brain) of control mice; no expression of RAG-1 mRNA was detected in spinal cord or brain from
doi:10.2172/10175212 fatcat:lkdzxkwgojcmrgxaa732fjv6ky