Silver salts and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols with trifluoromethyl ketones

Jingjing Wang, Wei-Guang Kong, Feng Li, Jie Liu, Qin Shen, Lantao Liu, Wen-Xian Zhao
2015 Organic and biomolecular chemistry  
A general and efficient synthesis of trifluoromethyl substituted 5-alkylidene-1,3-dioxolane using a silver salt and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols and trifluoromethyl ketones is described.
doi:10.1039/c5ob00438a pmid:25858542 fatcat:32vms2q63jhobflsn7w4b5vlzm