Polyunsaturated fatty acids (PUFA) regulate neurotransmitter contents in rat brain

S Varghese, B Shameena, P S Lakshmy, M P Biju, P N Easwar Shankar, C S Paulose, O V Oommen
2001 Indian Journal of Biochemistry & Biophysics  
The effects of feeding of 6-propylthiouracil (6-PTU) and polyunsaturated fatty acids (PUFA) independently and in combination and administration (ip) of a single dose of triiodothyronine (T3) (2.5 microg/100 g body wt) along with feeding of 6-PTU and PUFA were studied in rat brain. Dopamine (DA), 5-hydroxytryptophan (5-HTP), serotonin (5-HT), 5-hydroxy indole acetic acid (5-HIAA), norepinephrine (NE) and epinephrine (EPI) contents were assayed in the hypothalamus and cerebral cortex regions. It
more » ... as found that 6-PTU feeding resulted in decrease in dopamine, 5-HT, 5-HTP and 5-HIAA in both regions. In animals fed with PUFA followed by administration of T3, the DA level was found normal.
pmid:11886081 fatcat:qyo45wtjo5h3thkkjvor5k3b74