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StructureActivity Relationship Studies of Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family
The phospholipase A and acyltransferase (PLAAT) family of cysteine hydrolases consists of five members, which are involved in the Ca 2+ -independent production of N-acylphosphatidylethanolamines (NAPEs). NAPEs are lipid precursors for bioactive N-acylethanolamines (NAEs) that are involved in various physiological processes such as food intake, pain, inflammation, stress, and anxiety. Recently, we identified α-ketoamides as the first pan-active PLAAT inhibitor scaffold that reduced arachidonicdoi:10.1021/acs.jmedchem.0c00522.s002 fatcat:asoqhtblafe5dnfbm5j6yeeslu