Sedentary Behavior and Cardiovascular Disease Risk

Sophie Carter, Yvonne Hartman, Sophie Holder, Dick H. Thijssen, Nicola D. Hopkins
2017 Exercise and sport sciences reviews  
1 Sedentary behavior (SB) has a strong association with cardiovascular disease (CVD) risk which 2 may be independent of physical activity. To date, the mechanism(s) which mediate this 3 relationship are poorly understood. We hypothesize that SB modifies key hemodynamic, 4 inflammatory and metabolic processes resulting in impaired arterial health. Subsequently, 5 these vascular impairments directly and indirectly contribute to the development of CVD. 6 7 SUMMARY 8 Sedentary behavior modulates
more » ... havior modulates key stimuli that impair arterial health, directly and indirectly 9 contributing to the development of cardiovascular disease. 10 11 KEY POINTS 12  Sedentary behavior (SB: i.e. sitting, lying) is associated with numerous negative health 13 connotation. Previous work has predominantly focused on the relationship between SB 14 and all-cause mortality and/or metabolic disorders, yet the relationship between SB and 15 the development of cardiovascular disease (CVD) has received less attention. 16  Recent evidence suggests that the negative effects of SB on markers of vascular health, 17 and to a lesser degree traditional CVD risk factors, are likely responsible for the 18 increased CVD incidence and mortality associated with SB. 19  We propose that SB induced down regulation of shear rate and blood flow, as well as 1 alterations to glucose metabolism and inflammatory and oxidative stress pathways are 2 likely to play a key role in the vascular dysfunction associated with SB. 3 4 KEY WORDS 5 Sitting, physical activity, vascular function, shear stress, cardiovascular risk factors 6 GLOSSARY 7
doi:10.1249/jes.0000000000000106 pmid:28118158 fatcat:aztrsd5d5ndznizfgzpgkoaymy