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Serotonin Depletion Induces 'Waiting Impulsivity' on the Human Four-Choice Serial Reaction Time Task: Cross-Species Translational Significance
2014
Neuropsychopharmacology
Convergent results from animal and human studies suggest that reducing serotonin neurotransmission promotes impulsive behavior. Here, serotonin depletion was induced by the dietary tryptophan depletion procedure (TD) in healthy volunteers to examine the role of serotonin in impulsive action and impulsive choice. We used a novel translational analog of a rodent 5-choice serial reaction time task (5-CSRTT)-the human 4-CSRTT-and a reward delay-discounting questionnaire to measure effects on these
doi:10.1038/npp.2013.351
pmid:24385133
pmcid:PMC3988556
fatcat:erzzwx2ifnf47j5mvqrm4puxr4