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The experimental activity of a new clinically confirmed antitumor compound, Vincaleukoblastine (C46HssOgN4), (VLB) as the sulfate has been described. Greatest activity was seen against the P-1534 acute lymphocytic leukemia in DBA/~ mice. Late as well as early stages of this leukemia were significantly affected by this compound. No synergistic or additive effects have been observed in combination therapy with other antitumor compounds. A second indole-indoline alkaloid, leurosine, isomeric withpmid:14407465 fatcat:tqonaawu2bbz5krw4pr7kzyo44