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Conclusions: This study indicates that the effect of radiation dose on the local lung damage may be partially detected already during RT using CBCT image analysis. If a high LuRa value is shown to be a good surrogate endpoint for clinical toxicity and the results of the current investigational study are validated, the proposed response models may provide an assay for identifying a subgroup of low-responsive patients as potential candidates for safe dose escalation.doi:10.1016/s0167-8140(15)40620-6 fatcat:kngn7wys5bewnolk4v6bqblmaa