Congenital Long-QT Syndrome (LQTS) is a genetic disorder affecting the repolarization of the heart. The most prevalent subtypes of LQTS are LQT1-3. In this work, we aim to evaluate the differences in the T-waves of simulated LQT1-3 in order to identify markers in the ECG that might help to classify patients solely based on ECG measurements. For LQT1, mutation S277L was used to characterize I Ks and mutation S818L in I Kr for LQT2. Voltage clamp data were used to parametrize the ion channel

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... ions of the ten Tusscher and Panfilov model of human ventricular electrophysiology. LQT3 was integrated using an existing mutant I N a model. The monodomain model was used in a transmural and apico-basal heterogeneous model of the ventricles to calculate ventricular excitation propagation. The forward calculation on a torso model was performed to determine body surface ECGs. Compared to the physiological case with a QT-time of 375 ms, this interval was prolonged in all LQTS (LQT1 423 ms; LQT2 394 ms; LQT3 405 ms). The T-wave amplitude was changed (Einthoven lead II: LQT1 108%; LQT2 91%; LQT3 103%). Also, the width of the T-wave was enlarged (full width at half maximum: LQT1 111%; LQT2 125%; LQT3 109%). At the current state of modeling and data analysis, the three LQTS have not been distinguishable solely by ECG data.