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Dehydroepiandrosterone administration prevents the oxidative damage induced by acute hyperglycemia in rats
Journal of Endocrinology
Free radical overproduction contributes to tissue damage induced by acute hyperglycemia. Dehydroepiandrosterone, which has recently been found to have antioxidant properties, was administered i.p. to rats at different doses (10, 50 or 100 mg/kg body weight) 3 h before treatment with dextrose (5 g/kg). Lipid peroxidation was evaluated on liver, brain and kidney homogenates, measuring both steady-state concentrations of thiobarbituric acid reactive substances, and fluorescent chromolipids,doi:10.1677/joe.0.1550233 pmid:9415057 fatcat:mw6wjezctjephhkxxkxftiijmu