A Low-cost and Portable Near-infrared Spectrometer using Open-source Multivariate Data Analysis Software for Rapid Discriminatory Quality Assessment of Medroxyprogesterone Acetate Injectables

Matthew Eady, Michael Payne, Steve Sortijas, Ed Bethea, David Jenkins
<span title="2021-05-05">2021</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ajb3xxyezbfrhoytrewaenlyla" style="color: black;">Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy</a> </i> &nbsp;
Medroxyprogesterone acetate (MPA) injectable suspensions are used by millions of women for family planning and hormonal therapy. Falsified or substandard medications may result in a health risk for consumers. Near-infrared spectroscopy (NIR) has previously been applied as a means of non-destructive and rapid screening of product quality compliance. These methods offer advantages but can be logistically and cost prohibitive for field use in resource limited areas. Here, a handheld spectrometer
more &raquo; ... 00-1700 nm) with open-sourced software is used to evaluate vials of MPA from three suppliers (N = 227 vials) and verified by a benchtop UV-VIS-NIR (350-2500 nm) with licensed software. Multivariate data analysis assesses the spectral signatures of samples and builds a discriminant classification method based on Mahalanobis distances calculated from a principal component analysis scores. The handheld device paired with open-source software resulted in a product discrimination accuracy of 100% (verified by benchtop UV-VIS-NIR and chemical testing data) as well indicating that the low-cost field portable device is suitable for rapidly assessing samples in resource limited areas for consistency of manufacturing and sourcing.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.saa.2021.119917">doi:10.1016/j.saa.2021.119917</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33991812">pmid:33991812</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6xtd7tsnmrabxap732jvhaszze">fatcat:6xtd7tsnmrabxap732jvhaszze</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210528175024/https://pdf.sciencedirectassets.com/271973/1-s2.0-S1386142521X00108/1-s2.0-S1386142521004935/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjELn%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJIMEYCIQCjVTZEg3fIf1DhMOdlI36Miool5qHArKTtOxFBGK4RogIhAOwZElY8PPhJlBXj8SiQiz5i%2FtZjh%2Ft4cRvRCzdr%2FtK0KvoDCGIQBBoMMDU5MDAzNTQ2ODY1IgxkwJtlbLnDz9m053Qq1wNQNtb1TFxJ7mrBRE7sDqZtHhYnyR5h9CP6yJbP1GnejJz4PdoCzpkL6crUREcOEj2AVJdbgQfJxcpir7yzaNBFnupDj5Q35UVsPMFee23aE%2Fwh2LAUmmiEZTeGkBvkQcFfh0j7Vx5lpUEAOF%2FjX6RbADECAO9a66cddvIsX64EWkV7P5YD5B4kTT9XRpZjhPZt52seoYyhDuDMrZA6oL%2B9fKNlBjNOYqnaHnlKot1Khwx4LOI2b36pzhCh6F%2F%2BrxqCzzFNTBhS9lL9DDhji3ZGpkYd9i7kfqKXDT2J3i9%2FTGt6g0T6ojNlEhd3TjwQtySV7N00rHe0%2BdD335mFtxoeGp7YhaEnKt9H1s7NS1mqAY1%2B2e4HzgjJ3NRmPwBlbtx3oW%2BPJ9HgwazekU3BQbIR%2BnSk6dWSpIu8lTacpGHBfrVf%2BgOWou5tdcT78x%2FZFZ8LoA3i96j7cpfAobhN69JvvGTSWZp7VDaUwHJgD4mrVg%2BEF84s4uXT81nVpblUQ02KXxSoirVXj7Y0oYjUV2RJWrpULiXsjV3%2BptSYJPqVTOJj3gl0wiq9YXXJp5zuPWBIK12U31X%2FvIWi7Mwzb5rHvgk2s5XUEb2NRVGRLkC9bTjKE%2B6OloIw0MLEhQY6pAHKv6XyBBFd70dCEkd2iNJukFoOvGwPKdOia%2Bvuo9hXOQc8zbXukNKX0wFoQON2I4VzWe6agCxJ%2BZg%2FzihARMgkwdkiILjKp%2FBAWc5n0G0BYpJhPVRwwGMCUkcHLxVgfZ9klf0FSq94sFD6KmDAS3e752%2Beaiez7frY73IQNSMg56TH3XcS5fuJSHO8X7tuldxLjTPQE70jj1Wx8qzL803zslghVA%3D%3D&amp;X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;X-Amz-Date=20210528T175020Z&amp;X-Amz-SignedHeaders=host&amp;X-Amz-Expires=300&amp;X-Amz-Credential=ASIAQ3PHCVTYQ6RQSH3E%2F20210528%2Fus-east-1%2Fs3%2Faws4_request&amp;X-Amz-Signature=e49ebdc11d3e6b29531e98fac7e0882d4d1df8b1bf9bae2ce65a0c2f981f76ed&amp;hash=937688a105b7dc902d0270e0e55cdb1591bd53b1de516399012a075de8b22209&amp;host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&amp;pii=S1386142521004935&amp;tid=spdf-215f5fdf-dc8b-447e-9d03-b0e97fc91394&amp;sid=bb88743054e2394e068a31947f1fc97c8512gxrqa&amp;type=client" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/21/a7/21a77685d3f99e731449a2289f8a7225fbc9e398.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.saa.2021.119917"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a>