A Low-cost and Portable Near-infrared Spectrometer using Open-source Multivariate Data Analysis Software for Rapid Discriminatory Quality Assessment of Medroxyprogesterone Acetate Injectables

Matthew Eady, Michael Payne, Steve Sortijas, Ed Bethea, David Jenkins
2021 Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy  
Medroxyprogesterone acetate (MPA) injectable suspensions are used by millions of women for family planning and hormonal therapy. Falsified or substandard medications may result in a health risk for consumers. Near-infrared spectroscopy (NIR) has previously been applied as a means of non-destructive and rapid screening of product quality compliance. These methods offer advantages but can be logistically and cost prohibitive for field use in resource limited areas. Here, a handheld spectrometer
more » ... 00-1700 nm) with open-sourced software is used to evaluate vials of MPA from three suppliers (N = 227 vials) and verified by a benchtop UV-VIS-NIR (350-2500 nm) with licensed software. Multivariate data analysis assesses the spectral signatures of samples and builds a discriminant classification method based on Mahalanobis distances calculated from a principal component analysis scores. The handheld device paired with open-source software resulted in a product discrimination accuracy of 100% (verified by benchtop UV-VIS-NIR and chemical testing data) as well indicating that the low-cost field portable device is suitable for rapidly assessing samples in resource limited areas for consistency of manufacturing and sourcing.
doi:10.1016/j.saa.2021.119917 pmid:33991812 fatcat:6xtd7tsnmrabxap732jvhaszze