Transplantation of human umbilical cord blood-derived mononuclear cells induces recovery of motor dysfunction in a rat model of Parkinson's disease

Fabin Han, Zhongchao Han, Chao Chen, Jing Duan, Aifang Shen, Wei Wang, Hao Song, Yanming Liu, Xianjie Lu, Xiaobing Wang, Zhiqing You
2016 Journal of Neurorestoratology  
Journal of Neurorestoratology Dovepress submit your manuscript | www.dovepress.com Dovepress 23 O r i g i N a l r e s e a r c h open access to scientific and medical research Open access Full Text article http://dx. Abstract: Human umbilical cord blood-derived mononuclear cells (hUCB-MNCs) were reported to have neurorestorative capacity for neurological disorders such as stroke and traumatic brain injury. This study was performed to explore if hUCB-MNC transplantation plays any therapeutic
more » ... ny therapeutic effects for Parkinson's disease (PD) in a 6-OHDA-lesioned rat model of PD. hUCB-MNCs were isolated from umbilical cord blood and administered to the striatum of the 6-OHDA-lesioned rats. The apomorphine-induced locomotive turning-overs were measured to evaluate the improvement of motor dysfunctions of the rats after administration of hUCB-MNCs. We observed that transplanted hUCB-MNCs significantly improve the motor deficits of the PD rats and that grafted hUCB-MNCs integrated to the host brains and differentiated to neurons and dopamine neurons in vivo after 16 weeks of transplantation. Our study provided evidence that transplanted hUCB-MNCs play therapeutic effects in a rat PD model by differentiating to neurons and dopamine neurons.
doi:10.2147/jn.s98835 fatcat:b4ye5yzjzrc53ouczbqh5yjjpm