A facile method for the synthesis of N-(α-aminoacyl) sulfonamides

2012 Drug Discoveries & Therapeutics  
N-Acylsulfonamide derivatives have important applications in organic synthesis and drug discovery. It was found that many problems occurred preparing amino acid derived N-acylsulfonamides with the commonly used coupling approach in our previous studies. In this paper, we report an efficient approach to synthesize various amino acids derived N-acylsulfonamides in high yields without any racemization.
doi:10.5582/ddt.2012.v6.2.62 fatcat:dbha6y56fbfubf3rdj4bm6ljpu