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Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors
[article]
2020
bioRxiv
pre-print
Transcriptional silencing of HIV generates a reservoir of latently infected cells, but the mechanisms that lead to this outcome are not well understood. We characterized a primary cell model of HIV latency, and observed that latency is a stable, heritable viral state that is rapidly reestablished after stimulation. Using Assay of Transposon-Accessible Chromatin sequencing (ATACseq) we found that latently infected cells exhibit reduced proviral accessibility, elevated activity of Forkead and
doi:10.1101/2020.07.24.220012
fatcat:frgbb57alvfu3exjdrkuxgyete