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CREB non-autonomously regulates Reproductive Aging through Hedgehog/Patched Signalling
Evolutionarily conserved signaling pathways are crucial for adjusting growth, reproduction, and cell maintenance in response to altered environmental conditions or energy balance. However, we have an incomplete understanding of the signaling networks and mechanistic changes that coordinate physiological changes across tissues. We found that loss of the cAMP response element-binding protein (CREB) transcription factor significantly slows Caenorhabditis elegans reproductive decline, an earlydoi:10.1101/2020.03.02.972018 fatcat:krnl7dpxzfdvtlirukmnqwkuaq