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Clustering molecular network is a typical method in system biology, which is effective in predicting protein complexes or functional modules. However, few studies have realized that biological molecules are spatial-temporally regulated to form a dynamic cellular network and only a subset of interactions take place at the same location in cells. Results: In this study, considering the subcellular localization of proteins, we first construct a co-localization human protein interaction networkdoi:10.1186/s12859-019-2598-7 fatcat:ff5mzskb7ffw7asmc4meq7d33a