Original Article Effect of high-energy defibrillation on success rate of defibrillation and cardiac trauma in ventricular fibrillation pig model
Int J Clin Exp Med
This study aimed to explore effect of increased two-phase wave energy defibrillation on success rate of defibrillation and cardiac trauma based on current recommend energy using ventricular fibrillation pig model built by electrical stimulation in right ventricle. Twenty-four pigs were randomly divided recommend energy group (200 J), high-energy group (300 J) and ultra-high energy group (360 J). Total and the first defibrillation success rate, rate of return of spontaneous circulation (ROSC)
... rculation (ROSC) and the time of spontaneous circulation restoration were recorded. Left ventricular ejection fractions (LVEF) were examined before induced fibrillation, at 0 h and 24 h after ROSC, and change of serum BNP and serum markers were detected at 0 h, 2 h and 6 h after ROSC, respectively. Change of brain and neurological function, and pathomorphological changes of myocardial cells were observed under light microscope and electron microscope at 24 h after ROSC. Total defibrillation success rate in the ultra-high energy group was higher than the recommend energy group (P<0.05), but no significant difference was detected when other pairwise comparisons (P>0.05). LVEF was similar in each group at different time points (P>0.05), and no significant difference of serum BNP was detected between different groups at different time points (P>0.05). Myohemoglobin, troponin I and CK-MB had not significant difference between the three groups (P>0.05), while heart-type fatty acid binding protein was higher in the ultra-high energy group at 2 h and 6 h (P<0.05). Myocardial cells in each group were detected pathological changes under light microscope and electron microscope, but no significant difference was detected between groups. Mild damage in cerebral function was detected in the three groups, and no significant difference was detected pairwise comparison. The total success rate was higher using 360 J, and heart-type fatty acid binding protein was higher than the other groups. These findings implicate that ultra-high energy may have certain advantages, which may provide valuable reference for determining the optimal defibrillation energy.