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miR-203 inhibits cell growth and regulates G1/S transition by targeting Bmi-1 in myeloma cells
Molecular Medicine Reports
The oncogene B-cell-specific Moloney murine leukemia virus insertion site-1 (Bmi-1) is overexpressed in multiple myeloma (MM). Our previous study demonstrated that Bmi-1 silencing sensitized MM cells to bortezomib. Translational regulation has emerged as a prominent underlying mechanism of Bmi-1 regulation, particularly via microRNA targeting. The present study determined that Bmi-1 may be directly targeted by miR-203 using a luciferase assay. In addition, enforced expression of miR-203 led todoi:10.3892/mmr.2016.5832 pmid:27748826 fatcat:eelyhehmonak3kjwpyzm52bs7y