Originating from the β cells of Langerhans islets, insulinoma has an incidence of 1 to 4 in one million in the general population, but is the most common tumor among pancreatic neuroendocrine tumors [1] . It can be life-threatening depending on the presence of hypoglycemia. It is diagnosed through clinical [anxiety, nervousness, tremor, sweating, feeling of hunger, palpitation, restlessness, angina, and especially the presence of the Whipple triad (hypoglycemia symptoms + low blood sugar + the

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... isappearance of symptoms upon glucose intake)] and laboratory findings. Radiological imaging is helpful in distinctive diagnosis and determination of the operation procedure. Insulinoma diagnosis is supported by C peptide >0.6 ng/ml, insulin >3 µIU/mL, proinsulin >5 pmol/L, simultaneously with hypoglycemia (plasma glucose <55 mg/dl) [1,2]. Editorial iMedPub Journals